The coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created havoc worldwide.Due to the non-availability of any vaccine or drugs against COVID-19, immunotherapies involving convalescent plasma, immunoglobulins, antibodies (monoclonal or polyclonal), and the use of immunomodulator
The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors
Abstract The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease Mpro to cleave the virus-encoded polyproteins.Despite a wealth of experimental information already available, there is wide disagreement about the Mpro monomer-dimer equilibrium dissociation constant.Sin
Correlates of weight status among Norwegian 11-year-olds: The HEIA study
Abstract Background The underlying mechanisms of overweight and obesity in adolescents are still not fully understood.The aim of this study was to investigate modifiable and non-modifiable correlates of weight status among 1103 Norwegian 11-year-old adolescents Order Racks in the HEalth in Adolescents (HEIA) study, including demographic factors suc